Abstract

The efficacy of citrate and nadroparin anticoagulation for CVVH was similar, however, citrate was safer. Unexpectedly, citrate reduced mortality. Less bleeding could only partly explain this benefit, less clotting could not. Post hoc citrate appeared particularly beneficial after surgery, in sepsis and severe multiple organ failure, suggesting interference with inflammation.

Keywords

MedicineInterquartile rangeDiscontinuationRenal replacement therapyAnesthesiaIntensive care unitAdverse effectMetabolic alkalosisHemofiltrationAcute kidney injurySurgeryInternal medicineHemodialysis

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Publication Info

Year
2009
Type
article
Volume
37
Issue
2
Pages
545-552
Citations
326
Access
Closed

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Cite This

Heleen M. Oudemans–van Straaten, Rob J. Bosman, Matty Koopmans et al. (2009). Citrate anticoagulation for continuous venovenous hemofiltration*. Critical Care Medicine , 37 (2) , 545-552. https://doi.org/10.1097/ccm.0b013e3181953c5e

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DOI
10.1097/ccm.0b013e3181953c5e