Keywords
Computational biologyBiology
Affiliated Institutions
Related Publications
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signal...
Targeting the Wnt/β-catenin signaling pathway in cancer
Abstract The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis ...
SMART, a simple modular architecture research tool: Identification of signaling domains
Accurate multiple alignments of 86 domains that occur in signaling proteins have been constructed and used to provide a Web-based tool (SMART: simple modular architecture resear...
β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion
ABSTRACT We found that cultured human keratinocytes with high proliferative potential, the putative epidermal stem cells, expressed a higher level of noncadherin-associated β- c...
Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling
Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation of β-catenin, the...
Publication Info
- Year
- 1996
- Type
- letter
- Volume
- 382
- Issue
- 6586
- Pages
- 29-30
- Citations
- 43
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
43
OpenAlex
Cite This
Joan Massagué
(1996).
Crossing receptor boundaries.
Nature
, 382
(6586)
, 29-30.
https://doi.org/10.1038/382029a0
Identifiers
- DOI
- 10.1038/382029a0