Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Divij Mathew , Josephine R. Giles , Amy E. Baxter , Divij Mathew , Josephine R. Giles , Amy E. Baxter , Derek A. Oldridge , Allison R. Greenplate , Jennifer E. Wu , Cécile Alanio , Leticia Kuri-Cervantes , M. Betina Pampena , Kurt D’Andrea , Sasikanth Manne , Zeyu Chen , Yinghui Huang , John P. Reilly , Ariel R. Weisman , C.A.G. Ittner , Oliva Kuthuru , Jeanette Dougherty , Kito Nzingha , Nicholas Han , Justin Kim , Ajinkya Pattekar , Eileen C. Goodwin , Elizabeth M. Anderson , Madison E. Weirick , Sigrid Gouma , Claudia P. Arevalo , Marcus J. Bolton , Chen Fang , Simon F. Lacey , Holly Ramage , Sara Cherry , Scott E. Hensley , Sokratis A. Apostolidis , Alexander C. Huang , Laura A. Vella , Michael R. Betts , Nuala J. Meyer , E. John Wherry , Zahidul Alam , Mary M. Addison , Katelyn T. Byrne , Aditi Chandra , Hélène C. Descamps , Yaroslav Kaminskiy , Jacob T. Hamilton , Julia Han Noll , Dalia K. Omran , Eric Perkey , Elizabeth M. Prager , Dana Pueschl , Jennifer Shah , Jake Shilan , Ashley Vanderbeck
2020 Science 1,628 citations

Abstract

Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. Science , this issue p. eabc8511 , p. 1210

Keywords

Coronavirus disease 2019 (COVID-19)Profiling (computer programming)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Immune system2019-20 coronavirus outbreakVirologyBiologyMedicineImmunologyPathologyComputer scienceInfectious disease (medical specialty)DiseaseOutbreak

MeSH Terms

Adaptive ImmunityAdultAgedAged80 and overAntibodiesViralB-Lymphocyte SubsetsB-LymphocytesBetacoronavirusCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19Coronavirus InfectionsCytokinesFemaleHumansImmunologic MemoryLymphocyte ActivationMaleMiddle AgedPandemicsPlasma CellsPneumoniaViralSARS-CoV-2Severity of Illness IndexT-Lymphocyte SubsetsT-LymphocytesT-LymphocytesHelper-InducerTime FactorsYoung Adult

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Publication Info

Year
2020
Type
article
Volume
369
Issue
6508
Citations
1628
Access
Closed

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Divij Mathew, Josephine R. Giles, Amy E. Baxter et al. (2020). Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science , 369 (6508) . https://doi.org/10.1126/science.abc8511

Identifiers

DOI
10.1126/science.abc8511
PMID
32669297
PMCID
PMC7402624

Data Quality

Data completeness: 90%