Children's Hospital of Philadelphia

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

The basic composition of the human gut microbiome is influenced by long-term diet: high fat and protein versus high fiber.

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

In this global study of CAR T-cell therapy, a single infusion of tisagenlecleucel provided durable remission with long-term persistence in pediatric and young adult patients wit...

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Mendelian randomization of blood lipids for coronary heart disease

The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain.

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Structure and orientation of the antibiotic peptide magainin in membranes by solid‐state nuclear magnetic resonance spectroscopy

Abstract Magainin 2 is a 23‐residue peptide that forms an amphipathic α ‐helix in membrane environments. It functions as an antibiotic and is known to disrupt the electrochemica...

CAR: A virus receptor within the tight junction

The coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic inter...

Pharmacologically distinct sodium-dependentl-[3H]glutamate transport processes in rat brain

The transport of L-[3H]glutamate into crude synaptosomal membrane fractions prepared from cerebellum, brainstem, hippocampus, cortex, striatum, and midbrain was characterized. I...