Abstract
In a mouse model of multistage carcinogenesis elicited by the SV40 large T-antigen (Tag) oncogene in pancreatic beta cells, the gene for insulin-like growth factor IGF2 is focally up-regulated and functionally implicated in tumour development. The IGF2 gene is differentially regulated in normal tissues: the paternal allele is transiently expressed during embryogenesis, whereas the maternal allele is genomically imprinted and inactive. Crossbred mice carrying the Tag oncogene and a disruption of either the paternal or maternal allele of IGF2 reveal that both alleles are co-activated early during tumour development, and that each contributes to malignant hyperproliferation and consequent tumour volume.
Keywords
BiologyCarcinogenesisAlleleGeneGeneticsGenomic imprintingGrowth factorInsulinCancer researchInsulin-like growth factor 2Gene expressionEndocrinologyDNA methylation
MeSH Terms
AllelesAnimalsBase SequenceCell TransformationNeoplasticGene Expression RegulationNeoplasticGenomic ImprintingGenotypeInsulin-Like Growth Factor IIIslets of LangerhansMiceMiceInbred StrainsMiceKnockoutMiceTransgenicMolecular Sequence DataMuscle ProteinsPancreatic NeoplasmsPhenotypeRNALong NoncodingRNAMessengerRNAUntranslatedUp-Regulation
Affiliated Institutions
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Publication Info
- Year
- 1995
- Type
- article
- Volume
- 10
- Issue
- 2
- Pages
- 196-201
- Citations
- 124
- Access
- Closed
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Cite This
Gerhard Christofori,
Paul Naik,
Douglas Hanahan
(1995).
Deregulation of both imprinted and expressed alleles of the insulin–like growth factor 2 gene during β–cell tumorigenesis.
Nature Genetics
, 10
(2)
, 196-201.
https://doi.org/10.1038/ng0695-196
Identifiers
- DOI
- 10.1038/ng0695-196
- PMID
- 7663515