Abstract
Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al. elucidate how the binding of the DSG1 cytoplasmic tail to the scaffolding protein Erbin decreases signaling through the Ras-Raf pathway to promote stratification and differentiation of keratinocytes in the epidermis.
Keywords
Downregulation and upregulationDesmosomeDesmogleinCell biologyKeratinocyteDesmoglein 1BiologyEpidermis (zoology)Signal transductionCellular differentiationImmunologyCell cultureGeneticsCadherinAnatomyCellGeneAntibodyAutoantibody
MeSH Terms
Adaptor ProteinsSignal TransducingCell DifferentiationDesmoglein 1EpidermisFemaleHumansKeratinocytesMAP Kinase Signaling SystemMale
Affiliated Institutions
Related Publications
Application of a partial-thickness human ex vivo skin culture model in cutaneous wound healing study
A number of in vivo and ex vivo skin models have been applied to human wound healing studies. A reliable skin model, which recapitulates the features of human wound repair, is e...
β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion
ABSTRACT We found that cultured human keratinocytes with high proliferative potential, the putative epidermal stem cells, expressed a higher level of noncadherin-associated β- c...
Downregulation of 14-3-3σ Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes
In human epidermal keratinocytes, replicative senescence, is determined by a progressive decline of clonogenic and dividing cells. Its timing is controlled by clonal evolution, ...
Epidermal signal transduction and transcription factor activation in activated keratinocytes
In the area of biology, many laboratories around the world are dissecting and characterizing signal transduction mechanisms and transcription factors responsive to various growt...
Desmosomes: differentiation, development, dynamics and disease
Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter...
Publication Info
- Year
- 2013
- Type
- letter
- Volume
- 123
- Issue
- 4
- Pages
- 1419-1422
- Citations
- 55
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
55
OpenAlex
0
Influential
51
CrossRef
Cite This
Christoph M. Hammers,
John R. Stanley
(2013).
Desmoglein-1, differentiation, and disease.
Journal of Clinical Investigation
, 123
(4)
, 1419-1422.
https://doi.org/10.1172/jci69071
Identifiers
- DOI
- 10.1172/jci69071
- PMID
- 23524961
- PMCID
- PMC3613937