Desmosomes: differentiation, development, dynamics and disease

David R. Garrod; Martyn Chidgey; Alison J. North

doi:10.1016/s0955-0674(96)80108-6

Abstract

Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate the adhesive properties of desmosomes in epithelial cell sheets. Genetic studies indicate the involvement of desmosomal components in cancer and epidermal diseases.

Keywords

BiologyMorphogenesisCell biologyGene isoformCellular differentiationGlycoproteinGeneGenetics

Affiliated Institutions

University of Manchester GB

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Publication Info

Year: 1996
Type: review
Volume: 8
Issue: 5
Pages: 670-678
Citations: 162
Access: Closed

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APA Style

                            
                                    David R. Garrod, 
                                
                                    Martyn Chidgey, 
                                
                                    Alison J. North
                                
                            (1996). 
                            Desmosomes: differentiation, development, dynamics and disease. 
                            Current Opinion in Cell Biology
                            , 8
                            (5)
                            , 670-678.
                            https://doi.org/10.1016/s0955-0674(96)80108-6

Identifiers

DOI: 10.1016/s0955-0674(96)80108-6