Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer

Jianjiao Chen; Heng Cui; Xiaolu Wang; Yiying Zeng; Dongyue Pan; Jun Chen; Zhenhua Zhang; Yana An; Zhanfeng Gu; Guodi Cai; Hong Wang; Mengya Yu; Bin Yang; Shengning Zhou; Jianan Tan; Lan Liu; Junjian Wang; Jing Li; Fanghai Han

doi:10.1186/s12967-025-07323-3

Abstract

Taken together, these findings highlight that SREBP-1 is an effective therapeutic target in GC and that Pen-H is a promising SREBP-1 inhibitor and a candidate for GC treatment.

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Publication Info

Year: 2025
Type: article
Volume: 23
Issue: 1
Pages: 1390-1390
Citations: 0
Access: Closed

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APA Style

                            
                                
                                    Jianjiao Chen, 
                                
                                    Heng Cui, 
                                
                                    Xiaolu Wang
                                
                                et al.
                            
                            (2025). 
                            Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer. 
                            Journal of Translational Medicine
                            , 23
                            (1)
                            , 1390-1390.
                            https://doi.org/10.1186/s12967-025-07323-3
                        

Identifiers

DOI: 10.1186/s12967-025-07323-3