Abstract
These results suggest that the antitumor activity and possibly the toxicologic properties of 17AAG in humans may be influenced by the expression of DT-diaphorase. Careful monitoring for NQO1 polymorphism and the level of tumor DT-diaphorase activity is therefore recommended in clinical trials with 17AAG.
Keywords
Heat shock proteinTransfectionMolecular biologyCell cultureHsp27Hsp90Hsp90 inhibitorHsp70Cell growthCancer researchGrowth inhibitionBiologyChemistryBiochemistryGene
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Publication Info
- Year
- 1999
- Type
- article
- Volume
- 91
- Issue
- 22
- Pages
- 1940-1949
- Citations
- 349
- Access
- Closed
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Cite This
LR Kelland,
Swee Y. Sharp,
Paul Rogers
et al.
(1999).
DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90.
JNCI Journal of the National Cancer Institute
, 91
(22)
, 1940-1949.
https://doi.org/10.1093/jnci/91.22.1940
Identifiers
- DOI
- 10.1093/jnci/91.22.1940