Abstract
Abstract: Pharmacological inhibition of excitatory neurotransmission attenuates cell death in models of global and focal ischemia and hypoglycemia, and improves neurological outcome after experimental spinal cord injury. The present study examined the effects of the noncompetitive N ‐methyl‐d‐aspartate receptor blocker MK‐801 on neurochemical sequelae following experimental fluid‐percussion brain injury in the rat. Fifteen minutes after fluid‐percussion brain injury (2.8 atmospheres), animals received either MK‐801 (1 mg/ kg, i.v.) or saline. MK‐801 treatment significantly attenuated the development of focal brain edema at the site of injury 48 h after brain injury, significantly reduced the increase in tissue sodium, and prevented the localized decline in total tissue magnesium that was observed in injured tissue of saline‐treated animals. Using phosphorus nuclear magnetic resonance spectroscopy, we also observed that MK‐801 treatment improved brain metabolic status and promoted a significant recovery of intracellular free magnesium concentrations that fell precipitously after brain injury. These results suggest that excitatory amino acid neurotransmitters may be involved in the pathophysiological sequelae of traumatic brain injury and that noncompetitive N ‐methyl‐d‐aspartate receptor antagonists may effectively attenuate some of the potentially deleterious neurochemical sequelae of brain injury.
Keywords
NeurochemicalGlutamate receptorTraumatic brain injuryPharmacologyMedicineAnesthesiaInternal medicineChemistryEndocrinologyReceptor
MeSH Terms
Adenosine TriphosphateAnimalsAnticonvulsantsBody WaterBrainBrain EdemaBrain InjuriesCarbon DioxideCationsDibenzocycloheptenesDizocilpine MaleateHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyMaleOxygenPhosphatesPhosphocreatineRatsReceptorsN-Methyl-D-AspartateReceptorsNeurotransmitterReference Values
Affiliated Institutions
Related Publications
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Many cells grown in tissue culture adhere tightly to the underlying substrate through discrete regions of the plasma membrane, referred to as adhesion plaques, focal contacts, o...
Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration
Abstract Using a human amyloid β (Aβ) intracerebroventricular infusion mouse model of Alzheimer's disease‐related injury, we previously demonstrated that systemic administration...
Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis.
The interaction of homologous and heterologous albumin-gold complex (Alb-Au) with capillary endothelium was investigated in the mouse lung, heart, and diaphragm. Perfusion of th...
Processing strategies for time‐course data sets in functional mri of the human brain
Abstract Image processing strategies for functional magnetic resonance imaging (FMRI) data sets acquired using a gradient‐recalled echo‐planar imaging sequence are considered. T...
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study
Abstract Objective To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. Design Retrospective case series. Setting Tongji Hosp...
Publication Info
- Year
- 1990
- Type
- article
- Volume
- 55
- Issue
- 4
- Pages
- 1170-1179
- Citations
- 167
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
167
OpenAlex
2
Influential
144
CrossRef
Cite This
Tracy K. McIntosh,
Robert Vink,
Holly Soares
et al.
(1990).
Effect of Noncompetitive Blockade of <i>N</i>‐Methyl‐d‐Aspartate Receptors on the Neurochemical Sequelae of Experimental Brain Injury.
Journal of Neurochemistry
, 55
(4)
, 1170-1179.
https://doi.org/10.1111/j.1471-4159.1990.tb03122.x
Identifiers
- DOI
- 10.1111/j.1471-4159.1990.tb03122.x
- PMID
- 2168932