Abstract
A simple model for the evolution of the rate of molecular evolution is presented. With a Bayesian approach, this model can serve as the basis for estimating dates of important evolutionary events even in the absence of the assumption of constant rates among evolutionary lineages. The method can be used in conjunction with any of the widely used models for nucleotide substitution or amino acid replacement. It is illustrated by analyzing a data set of rbcL protein sequences.
Keywords
BiologyProtein evolutionMolecular evolutionRate of evolutionSimple (philosophy)Evolutionary biologyBayesian probabilitySubstitution (logic)Biological evolutionSet (abstract data type)Basis (linear algebra)Constant (computer programming)Computational biologyPhylogeneticsGeneticsStatisticsComputer scienceMathematicsGene
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Publication Info
- Year
- 1998
- Type
- article
- Volume
- 15
- Issue
- 12
- Pages
- 1647-1657
- Citations
- 1330
- Access
- Closed
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Cite This
Jeffrey L. Thorne,
Hirohisa Kishino,
Ian Painter
(1998).
Estimating the rate of evolution of the rate of molecular evolution.
Molecular Biology and Evolution
, 15
(12)
, 1647-1657.
https://doi.org/10.1093/oxfordjournals.molbev.a025892
Identifiers
- DOI
- 10.1093/oxfordjournals.molbev.a025892