Rasmus Nielsen

Stochastic Mapping of Morphological Characters

Many questions in evolutionary biology are best addressed by comparing traits in different species. Often such studies involve mapping characters on phylogenetic trees. Mapping ...

Mapping Mutations on Phylogenies

Mapping of mutations on a phylogeny has been a commonly used analytical tool in phylogenetics and molecular evolution. However, the common approaches for mapping mutations based...

The Use of Coded PCR Primers Enables High-Throughput Sequencing of Multiple Homolog Amplification Products by 454 Parallel Sequencing

We demonstrate that this new approach enables the assignment of virtually all the generated DNA sequences to the correct source once sequencing anomalies are accounted for (miss...

The diploid genome sequence of an Asian individual

Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We...

Estimation of allele frequency and association mapping using next-generation sequencing data

Overall, our results suggest that association mapping and estimation of allele frequencies should not be based on genotype calling in low to medium coverage data. Furthermore, i...

Design of association studies with pooled or un‐pooled next‐generation sequencing data

Abstract Most common hereditary diseases in humans are complex and multifactorial. Large‐scale genome‐wide association studies based on SNP genotyping have only identified a sma...

A metagenome-wide association study of gut microbiota in type 2 diabetes

Genotype and SNP calling from next-generation sequencing data

Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants