Abstract
This meta-analysis confirms that clozapine is more effective than conventional neuroleptics in reducing symptoms of patients with both treatment-resistant and nonresistant schizophrenia. Future trials should be long-term pragmatic community trials or should address the effectiveness of clozapine in special patient populations. An international standard set of outcomes, including pragmatic assessments of functioning, would greatly enhance the comparison and summation of trials and future assessments of effectiveness.
Keywords
ClozapineMeta-analysisSchizophrenia (object-oriented programming)Randomized controlled trialMaximPsychologyMedicinePsychiatryInternal medicinePhilosophy
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Publication Info
- Year
- 1999
- Type
- review
- Volume
- 156
- Issue
- 7
- Pages
- 990-999
- Citations
- 352
- Access
- Closed
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Cite This
Kristian Wahlbeck,
Maxim V. Cheine,
Adib Essali
et al.
(1999).
Evidence of Clozapine’s Effectiveness in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Trials.
American Journal of Psychiatry
, 156
(7)
, 990-999.
https://doi.org/10.1176/ajp.156.7.990
Identifiers
- DOI
- 10.1176/ajp.156.7.990