Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

Leslie Magtanong; Pin‐Joe Ko; Milton To; Jennifer Yinuo Cao; Giovanni C. Forcina; Amy Tarangelo; Carl C. Ward; Kevin Cho; Gary J. Patti; Daniel K. Nomura; James A. Olzmann; Scott J. Dixon

doi:10.1016/j.chembiol.2018.11.016

Keywords

LipotoxicityPolyunsaturated fatty acidProgrammed cell deathApoptosisBiochemistryReactive oxygen speciesChemistryCell biologyCellFatty acidLipidomicsBiologyEndocrinology

Affiliated Institutions

Related Publications

Ferroptosis: machinery and regulation

Xin Chen , Jingbo Li , Rui Kang +2 more

Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. T...

2020 Autophagy 1778 citations

Oxidative Stress and Cell Signalling

Giuseppe Poli , Gabriella Leonarduzzi , Fiorella Biasi +1 more

An increasing body of evidence from animal models, human specimens and cell lines points to reactive oxygen species as likely involved in the pathways, which convey both extrace...

2004 Current Medicinal Chemistry 705 citations

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon , Georg E. Winter , Leila Musavi +5 more

Little is known about the regulation of nonapoptotic cell death. Using massive insertional mutagenesis of haploid KBM7 cells we identified nine genes involved in small-molecule-...

2015 ACS Chemical Biology 964 citations

Heat stress induces ferroptosis-like cell death in plants

Ayelén Mariana Distéfano , María Victoria Martin , Juan Pablo Córdoba +11 more

In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iro...

2017 The Journal of Cell Biology 246 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

Thomas M. Johnson , Zu‐Xi Yu , V J Ferrans +2 more

Reactive oxygen species (ROS) have been implicated as potential modulators of apoptosis. Conversely, experiments under hypoxic conditions have suggested that apoptosis could occ...

1996 Proceedings of the National Academy o... 585 citations

Publication Info

Year: 2019
Type: article
Volume: 26
Issue: 3
Pages: 420-432.e9
Citations: 1017
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1017

OpenAlex

Cite This

APA Style

                            
                                
                                    Leslie Magtanong, 
                                
                                    Pin‐Joe Ko, 
                                
                                    Milton To
                                
                                et al.
                            
                            (2019). 
                            Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. 
                            Cell chemical biology
                            , 26
                            (3)
                            , 420-432.e9.
                            https://doi.org/10.1016/j.chembiol.2018.11.016
                        

Identifiers

DOI: 10.1016/j.chembiol.2018.11.016