Abstract

In a cohort of 38 patients with severe acute respiratory syndrome (SARS), we observed leukopenia in 47% of patients, lymphopenia in 84%, and T lymphopenia in 95%. CD4(+) T lymphocyte levels were reduced in 100% of patients, CD8(+) T lymphocyte levels were reduced in 87%, B lymphocyte levels were reduced in 76%, and natural killer cell levels were reduced in 55%. Our data suggested that these patients' immune systems were impaired during the course of SARS. The absolute counts of lymphocyte subsets demonstrated a clinical significance for patients with SARS.

Keywords

LymphocyteLeukopeniaImmunologyMedicineCD8Immune systemRespiratory systemSevere acute respiratory syndromeT lymphocyteLymphocytopeniaLymphocyte subsetsInternal medicineCoronavirus disease 2019 (COVID-19)ToxicityDisease

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Publication Info

Year
2003
Type
article
Volume
37
Issue
6
Pages
857-859
Citations
188
Access
Closed

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Wei Cui, Ying Fan, Wei Wu et al. (2003). Expression of Lymphocytes and Lymphocyte Subsets in Patients with Severe Acute Respiratory Syndrome. Clinical Infectious Diseases , 37 (6) , 857-859. https://doi.org/10.1086/378587

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DOI
10.1086/378587