Ferroptosis Inhibition: Mechanisms and Opportunities

Keywords

GPX4Programmed cell deathLipid peroxidationPhospholipid-hydroperoxide glutathione peroxidaseCell biologyBiologyCellChemistryApoptosisOxidative stressBiochemistryGlutathione peroxidaseSuperoxide dismutase

Affiliated Institutions

Related Publications

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Dongxue Xu , Fan Jiang , Zhiyong Peng +5 more

Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved me...

2019 Oxidative Medicine and Cellular Longe... 1931 citations

Ferroptosis: machinery and regulation

Xin Chen , Jingbo Li , Rui Kang +2 more

Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid peroxidation, which is controlled by integrated oxidation and antioxidant systems. T...

2020 Autophagy 1778 citations

Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis

Qitao Ran , Hanyu Liang , Minjun Gu +6 more

Glutathione peroxidase 4 (Gpx4) is uniquely involved in the detoxification of oxidative damage to membrane lipids. Our previous studies showed that Gpx4 is essential for mouse s...

2004 Journal of Biological Chemistry 254 citations

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson , Raúl Castro-Portuguez , Donna D. Zhang

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that cou...

2019 Redox Biology 2094 citations

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker , Joseph M. Hendricks , Zhipeng Li +11 more

2019 Nature 3211 citations

Publication Info

Year: 2017
Type: review
Volume: 38
Issue: 5
Pages: 489-498
Citations: 549
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Ferroptosis Inhibition: Mechanisms and Opportunities

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

549

OpenAlex

Cite This

APA Style

                            
                                
                                    José Pedro Friedmann Angeli, 
                                
                                    Ron Shah, 
                                
                                    Derek A. Pratt
                                
                                et al.
                            
                            (2017). 
                            Ferroptosis Inhibition: Mechanisms and Opportunities. 
                            Trends in Pharmacological Sciences
                            , 38
                            (5)
                            , 489-498.
                            https://doi.org/10.1016/j.tips.2017.02.005
                        

Identifiers

DOI: 10.1016/j.tips.2017.02.005