Abstract
A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 °C. FINO2 was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.
Keywords
ApoptosisPeroxideProgrammed cell deathCancer cellChemistryDioxolaneCell biologyReactive oxygen speciesCancerRing (chemistry)Cancer researchBiologyBiochemistryGeneticsMedicinal chemistry
Affiliated Institutions
Related Publications
Targeting ferroptosis as a vulnerability in cancer
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has ...
Heat stress induces ferroptosis-like cell death in plants
In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iro...
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that cou...
Ferroptosis as a target for protection against cardiomyopathy
Significance Nonapoptotic cell death-induced tissue damage has been implicated in a variety of diseases, including neurodegenerative disorder, inflammation, and stroke. In this ...
Nitrogen dioxide-induced changes in cell membrane fluidity and function.
Nitrogen dioxide (NO2), an environmental oxidant pollutant, is toxic to lung cells. One of the postulated mechanisms of NO2-induced pulmonary injury involves peroxidation of mem...
Publication Info
- Year
- 2016
- Type
- article
- Volume
- 11
- Issue
- 5
- Pages
- 1305-1312
- Citations
- 173
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
173
OpenAlex
Cite This
Rachel P. M. Abrams,
William L. Carroll,
K. A. Woerpel
(2016).
Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells.
ACS Chemical Biology
, 11
(5)
, 1305-1312.
https://doi.org/10.1021/acschembio.5b00900
Identifiers
- DOI
- 10.1021/acschembio.5b00900