Abstract
The extent to which the nucleus is functionally organized has broad biological implications. Evidence supports the idea that basic nuclear functions, such as transcription, are structurally integrated within the nucleus. Moreover, recent studies indicate that the linear arrangement of genes within eukaryotic genomes is nonrandom. We suggest that determining the relationship between nuclear organization and the linear arrangement of genes will lead to a greater understanding of how transcriptomes, dedicated to a particular cellular function or fate, are coordinately regulated. Current network theories may provide a useful framework for modeling the inherent complexity the functional organization of the nucleus.
Keywords
BiologyNucleusComputational biologyGenomeFunction (biology)Transcription factorGenomic organizationCell nucleusGeneGene regulatory networkTranscriptomeRegulation of gene expressionGeneticsEvolutionary biologyGene expressionCell biology
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Publication Info
- Year
- 2004
- Type
- review
- Volume
- 18
- Issue
- 12
- Pages
- 1371-1384
- Citations
- 295
- Access
- Closed
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Cite This
Steven T. Kosak,
Mark Groudine
(2004).
Form follows function: the genomic organization of cellular differentiation.
Genes & Development
, 18
(12)
, 1371-1384.
https://doi.org/10.1101/gad.1209304
Identifiers
- DOI
- 10.1101/gad.1209304