Fred Hutch Cancer Center

Integrated analysis of multimodal single-cell data

ezSingleCell is an interactive and easy-to-use application for the analysis of multiple single-cell and spatial omics data types for biologists. It combines the best-performing ...

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Chromosomal Mapping The conformation of the genome in the nucleus and contacts between both proximal and distal loci influence gene expression. In order to map genomic contacts,...

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

Antibody-mediated blockade of PD-L1 induced durable tumor regression (objective response rate of 6 to 17%) and prolonged stabilization of disease (rates of 12 to 41% at 24 weeks...

Circulating microRNAs as stable blood-based markers for cancer detection

Improved approaches for the detection of common epithelial malignancies are urgently needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs (miRNAs) ...

Massively parallel digital transcriptional profiling of single cells

Dimensionality reduction for visualizing single-cell data using UMAP

Advances in single-cell technologies have enabled high-resolution dissection of tissue composition. Several tools for dimensionality reduction are available to analyze the large...

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing