Abstract
This article reviews the mechanisms of gene silencing in cancer and clinical applications of this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key event in the development of cancer. The silencing can be effected by a disabling mutation or by a shutting down of the promoter region, the site at which transcription of the gene begins.
Keywords
Gene silencingGeneGeneticsDNA methylationTranscription (linguistics)MedicineBiologyCancer researchGene expression
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Publication Info
- Year
- 2003
- Type
- review
- Volume
- 349
- Issue
- 21
- Pages
- 2042-2054
- Citations
- 3378
- Access
- Closed
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Cite This
James G. Herman,
Stephen B. Baylin
(2003).
Gene Silencing in Cancer in Association with Promoter Hypermethylation.
New England Journal of Medicine
, 349
(21)
, 2042-2054.
https://doi.org/10.1056/nejmra023075
Identifiers
- DOI
- 10.1056/nejmra023075