Scott E. Kern

Definition of a consensus binding site for p53

Identification of p53 as a Sequence-Specific DNA-Binding Protein

The tumor-suppressor gene p53 is altered by missense mutation in numerous human malignancies. However, the biochemical properties of p53 and the effect of mutation on these prop...

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this fun...

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this e...

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers