Abstract

A method is suggested for the synthesis of multicomponent peptide mixtures. The method is a solid phase synthesis modified in order to give a closely equimolar mixture of peptides with predetermined sequences. The main point of modification is that before every coupling cycle the resin is divided into equal parts and each portion is coupled with a different amino acid. Then the portions are mixed and before the next coupling cycle the resin is again distributed into equal portions. The method is illustrated by the synthesis of a mixture of 27 tetrapeptides and that of 180 pentapeptides.

Keywords

Peptide synthesisPeptideCoupling (piping)Phase (matter)ChemistryCombinatorial chemistryAmino acidChromatographyMaterials scienceOrganic chemistryBiochemistryComposite material

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Publication Info

Year
1991
Type
article
Volume
37
Issue
6
Pages
487-493
Citations
1146
Access
Closed

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Árpád Furka, Ferenc Sebestyén, MAMO ASGEDOM et al. (1991). General method for rapid synthesis of multicomponent peptide mixtures. International journal of peptide & protein research , 37 (6) , 487-493. https://doi.org/10.1111/j.1399-3011.1991.tb00765.x

Identifiers

DOI
10.1111/j.1399-3011.1991.tb00765.x