Genetic Patterns in Head and Neck Cancers That Contain or Lack Transcriptionally Active Human Papillomavirus

Boudewijn J.M. Braakhuis; Peter J.F. Snijders; Willem‐Jan Keune; Chris J.L.M. Meijer; Henrique J. Ruijter-Schippers; C. René Leemans; Ruud H. Brakenhoff

doi:10.1093/jnci/djh183

Abstract

HNSCCs with transcriptionally active HPV16 DNA are characterized by occasional chromosomal loss, whereas HNSCCs lacking HPV DNA are characterized by gross deletions that involve whole or large parts of chromosomal arms and that already occur early in HNSCC development. These distinct patterns of genetic alterations suggest that HPV16 infection is an early event in HNSCC development.

Keywords

BiologyCarcinogenesisGeneDNACancer researchMutationCell cyclePolymerase chain reactionMolecular biologyGenetics

Affiliated Institutions

Amsterdam UMC Location Vrije Universiteit Amsterdam NL

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Publication Info

Year: 2004
Type: article
Volume: 96
Issue: 13
Pages: 998-1006
Citations: 406
Access: Closed

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APA Style

                            
                                
                                    Boudewijn J.M. Braakhuis, 
                                
                                    Peter J.F. Snijders, 
                                
                                    Willem‐Jan Keune
                                
                                et al.
                            
                            (2004). 
                            Genetic Patterns in Head and Neck Cancers That Contain or Lack Transcriptionally Active Human Papillomavirus. 
                            JNCI Journal of the National Cancer Institute
                            , 96
                            (13)
                            , 998-1006.
                            https://doi.org/10.1093/jnci/djh183
                        

Identifiers

DOI: 10.1093/jnci/djh183