Global quantification of mammalian gene expression control

Björn Schwanhäußer; Dorothea Busse; Na Li; Gunnar Dittmar; Johannes Schuchhardt; Jana Wolf; Wei Chen; Matthias Selbach

doi:10.1038/nature10098

Keywords

Messenger RNAGeneGene expressionBiologyTranslation (biology)Protein turnoverProtein biosynthesisGenomeTranscription (linguistics)Computational biologyRegulation of gene expressionGeneticsCell biology

Affiliated Institutions

Related Publications

Cellular functions of long noncoding RNAs

Run-Wen Yao , Yang Wang , Ling‐Ling Chen

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in ...

2019 Nature Cell Biology 1421 citations

Large-scale mRNA sequencing determines global regulation of RNA editing during brain development

Helene Wahlstedt , Chammiran Daniel , Mats Ensterö +1 more

RNA editing by adenosine deamination has been shown to generate multiple isoforms of several neural receptors, often with profound effects on receptor function. However, little ...

2009 Genome Research 292 citations

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

Ryan J.O. Dowling , Ivan Topisirović , Tommy Alain +10 more

Proliferation Control The protein complex mTORC1, which contains the protein kinase known as mammalian target of rapamycin, is an important regulator of cell proliferation and c...

2010 Science 745 citations

Global analysis of cellular protein translation by pulsed SILAC

Björn Schwanhäußer , Manfred Gossen , Gunnar Dittmar +1 more

Abstract Current methods for system‐wide gene expression analysis detect changes in mRNA abundance, but neglect regulation at the level of translation. Pulse labeling with stabl...

2008 PROTEOMICS 355 citations

Developmentally Regulated Activation of a SINE B2 Repeat as a Domain Boundary in Organogenesis

Victoria V. Lunyak , Gratien G. Préfontaine , Esperanza Núñez +11 more

The temporal and spatial regulation of gene expression in mammalian development is linked to the establishment of functional chromatin domains. Here, we report that tissue-speci...

2007 Science 278 citations

Publication Info

Year: 2011
Type: article
Volume: 473
Issue: 7347
Pages: 337-342
Citations: 6592
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Global quantification of mammalian gene expression control

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

6592

OpenAlex

Cite This

APA Style

                            
                                
                                    Björn Schwanhäußer, 
                                
                                    Dorothea Busse, 
                                
                                    Na Li
                                
                                et al.
                            
                            (2011). 
                            Global quantification of mammalian gene expression control. 
                            Nature
                            , 473
                            (7347)
                            , 337-342.
                            https://doi.org/10.1038/nature10098
                        

Identifiers

DOI: 10.1038/nature10098