Abstract
In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete DNA elements that contain specific sequence motifs with which DNA-binding proteins interact and transmit molecular signals to genes. Here, current models regarding the role of enhancers in the regulation of transcription by RNA polymerase II are presented.
Keywords
EnhancerTranscription (linguistics)RNA polymerase IIEnhancer RNAsBiologyGeneRNA polymeraseRNAGeneticsDNAComputational biologyCell biologyTranscription factorGene expressionPromoter
Affiliated Institutions
Related Publications
Enhanced gene expression by the poly(dT-dG).poly(dC-dA) sequence.
The sequence poly(dT-dG).poly(dC-dA) (TG-element) is a ubiquitous component of eucaryotic genomes and has the potential to adopt a left-handed DNA conformation (Z-DNA). In this ...
Revised transcription map of the late region of bacteriophage T7 DNA
The genes in the late region of the bacteriophage T7 genome are transcribed by a phage-specified RNA polymerase in two temporal classes (II and III). Through the use of an agaro...
Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication.
A target nucleic acid sequence can be replicated (amplified) exponentially in vitro under isothermal conditions by using three enzymatic activities essential to retroviral repli...
Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells
Transitions between pluripotent stem cells and differentiated cells are executed by key transcription regulators. Comparative measurements of RNA polymerase distribution over th...
Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
A method is described to synthesize small RNAs of defined length and sequence using T7 RNA polymerase and templates of synthetic DNA which contain the T7 promoter. Partially sin...
Publication Info
- Year
- 1998
- Type
- review
- Volume
- 281
- Issue
- 5373
- Pages
- 60-63
- Citations
- 824
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
824
OpenAlex
Cite This
Elizabeth M. Blackwood,
James T. Kadonaga
(1998).
Going the Distance: A Current View of Enhancer Action.
Science
, 281
(5373)
, 60-63.
https://doi.org/10.1126/science.281.5373.60
Identifiers
- DOI
- 10.1126/science.281.5373.60