Abstract

Abstract When crystals of organic compounds are grown in the presence of growth inhibitors, there is a change in crystal morphology. A stereochemical correlation exists between the crystal structure, its modified morphology, and the molecular structure of the inhibitor. This correlation has been successfully exploited for the efficient resolution of conglomerates, the engineering of organic crystals with desired morphologies, the direct and relative assignment of the absolute configurations of chiral molecules and crystals, and for the design of a new model for the spontaneous generation of optical activity. In an analogous way dissolution of organic crystals in the presence of these growth inhibitors induces etch pits at preselected faces. The effect of solvent on crystal growth has been analyzed in some model systems. The experimental results are complemented by atom‐atom potential energy calculations.

Keywords

DissolutionCrystal growthCrystal (programming language)MoleculeCrystal engineeringMorphology (biology)SolventChemistryResolution (logic)CrystallographyAtom (system on chip)Crystal structureOrganic moleculesSmall moleculeMaterials scienceChemical physicsStereochemistryOrganic chemistrySupramolecular chemistry

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Publication Info

Year
1985
Type
article
Volume
24
Issue
6
Pages
466-485
Citations
289
Access
Closed

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Cite This

Lia Addadi, Z. Berkovitch‐Yellin, Isabelle Weissbuch et al. (1985). Growth and Dissolution of Organic Crystals with “Tailor‐Made” Inhibitors—Implications in Stereochemistry and Materials Science. Angewandte Chemie International Edition in English , 24 (6) , 466-485. https://doi.org/10.1002/anie.198504661

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DOI
10.1002/anie.198504661

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Data completeness: 77%