Guidelines for performing Mendelian randomization investigations

Abstract

<ns4:p>This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.</ns4:p>

Keywords

Mendelian randomizationHarmonizationScope (computer science)Presentation (obstetrics)Computer scienceMendelian inheritancePsychologyMedicineBiologyGenetic variantsGeneticsSurgery

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Publication Info

Year: 2019
Type: preprint
Volume: 4
Pages: 186-186
Citations: 1768
Access: Closed

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APA Style

                            
                                    Stephen Burgess, 
                                
                                    George Davey Smith, 
                                
                                    Neil M Davies
                                
                                et al.
                            
                            (2019). 
                            Guidelines for performing Mendelian randomization investigations. 
                            Wellcome Open Research
                            , 4
                            
                            , 186-186.
                            https://doi.org/10.12688/wellcomeopenres.15555.1

Identifiers

DOI: 10.12688/wellcomeopenres.15555.1