Abstract
In a crossover connection, the polypeptide chain leaves one end of a beta sheet, forms a loop of any length and any conformation, and reenters the same beta sheet from the opposite end. Of the 85 examples of crossover connections which occur in the known protein structures, 83 are righthanded and only two are lefthanded. It is proposed that consistent handedness, even in long irregular loops, could be produced by the preferred twist direction of extended chain and the righthandedness of alpha-helices, provided certain conditions hold during the protein folding process.
Keywords
CrossoverBeta sheetLoop (graph theory)BETA (programming language)TwistFolding (DSP implementation)Connection (principal bundle)Protein foldingChain (unit)Protein structureCrystallographyPolypeptide chainCombinatoricsPhysicsChemistryMathematicsGeometryComputer scienceNuclear magnetic resonanceBiochemistryAmino acidEngineeringStructural engineeringArtificial intelligence
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Publication Info
- Year
- 1976
- Type
- article
- Volume
- 73
- Issue
- 8
- Pages
- 2619-2623
- Citations
- 176
- Access
- Closed
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Cite This
Jane S. Richardson
(1976).
Handedness of crossover connections in beta sheets..
Proceedings of the National Academy of Sciences
, 73
(8)
, 2619-2623.
https://doi.org/10.1073/pnas.73.8.2619
Identifiers
- DOI
- 10.1073/pnas.73.8.2619