How Fast-Folding Proteins Fold

Kresten Lindorff‐Larsen; Stefano Piana; Ron O. Dror; David E. Shaw

doi:10.1126/science.1208351

Abstract

Millisecond-scale molecular dynamics simulations of 12 proteins reveal a set of common principles for protein folding.

Keywords

Protein foldingFold (higher-order function)Folding (DSP implementation)Native stateProtein secondary structureMolecular dynamicsPhysicsContact orderDownhill foldingCrystallographyChemistryChemical physicsTopology (electrical circuits)Computational biologyBiophysicsBiologyPhi value analysisComputer scienceComputational chemistryMathematicsCombinatoricsEngineeringBiochemistry

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Publication Info

Year: 2011
Type: article
Volume: 334
Issue: 6055
Pages: 517-520
Citations: 1924
Access: Closed

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APA Style

                            
                                
                                    Kresten Lindorff‐Larsen, 
                                
                                    Stefano Piana, 
                                
                                    Ron O. Dror
                                
                                et al.
                            
                            (2011). 
                            How Fast-Folding Proteins Fold. 
                            Science
                            , 334
                            (6055)
                            , 517-520.
                            https://doi.org/10.1126/science.1208351
                        

Identifiers

DOI: 10.1126/science.1208351