Abstract

<i>Laetiporus sulphureus</i> mycelial extract (LSM) has shown potential as a pigmentation modulator. This study investigated the effects of LSM on melanogenesis in B16F10 cells. LSM significantly increased both extracellular and intracellular melanin content. It also upregulated tyrosinase protein expression and activity, along with MITF and β-catenin levels. LSM activated ERK1/2, p38, and JNK phosphorylation; however, only p38 inhibition suppressed LSM-induced melanin synthesis and the expression of melanogenesis-related proteins. Moreover, LSM increased the protein levels of Rho family GTPases (Cdc42, Rac1, RhoA), which was also blocked by p38 inhibition. These findings suggest that LSM promotes melanogenesis through p38 MAPK-dependent activation of β-catenin/MITF/tyrosinase axis and Rho GTPases, highlighting its potential as a natural pigmentation enhancer.

Affiliated Institutions

Related Publications

Publication Info

Year
2025
Type
article
Volume
35
Pages
e2510055-e2510055
Citations
0
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

0
OpenAlex

Cite This

So Jung Park, Hyeok Jin Choi, Jeong Won Choi et al. (2025). <i>Laetiporus sulphureus</i> Mycelial Extract Promotes Melanogenesis via p38 MAPK-Mediated Activation of β-Catenin/MITF and Rho Family Proteins in B16F10 Cells. Journal of Microbiology and Biotechnology , 35 , e2510055-e2510055. https://doi.org/10.4014/jmb.2510.10055

Identifiers

DOI
10.4014/jmb.2510.10055