In vivo genome editing restores haemostasis in a mouse model of haemophilia

Keywords

Genome editingZinc finger nucleaseBiologyGene targetingGeneGenomeGeneticsTranscription activator-like effector nucleaseComputational biologyHomology (biology)Locus (genetics)CRISPR

Affiliated Institutions

Related Publications

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

Chryssa Kanellopoulou , Stefan A. Muljo , Andrew L. Kung +5 more

Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post...

2005 Genes & Development 1237 citations

DNA polymerase of bacteriophage T4 is an autogenous translational repressor.

Mark Andrake , Nancy Guild , Tien Hsu +3 more

In bacteriophage T4 the protein product of gene 43 (gp43) is a multifunctional DNA polymerase that is essential for replication of the phage genome. The protein harbors DNA-bind...

1988 Proceedings of the National Academy o... 63 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

Roel Nusse , Harold Varmus

1982 Cell 1827 citations

Algorithmic challenges in mammalian whole‐genome assembly

Serafim Batzoglou

Abstract Sequencing of the human, mouse, and rat genomes was accomplished more quickly than had seemed feasible a mere eight years ago. The accelerating pace of sequencing has b...

2005 Encyclopedia of Genetics, Genomics, P... 9 citations

Homologous recombination in human embryonic stem cells

Thomas P. Zwaka , James A. Thomson

2003 Nature Biotechnology 664 citations

Publication Info

Year: 2011
Type: article
Volume: 475
Issue: 7355
Pages: 217-221
Citations: 538
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

In vivo genome editing restores haemostasis in a mouse model of haemophilia

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

538

OpenAlex

Cite This

APA Style

                            
                                
                                    Hojun Li, 
                                
                                    Virginia Haurigot, 
                                
                                    Yannick Doyon
                                
                                et al.
                            
                            (2011). 
                            In vivo genome editing restores haemostasis in a mouse model of haemophilia. 
                            Nature
                            , 475
                            (7355)
                            , 217-221.
                            https://doi.org/10.1038/nature10177
                        

Identifiers

DOI: 10.1038/nature10177