Abstract

The vitreous levels of the angiogenic polypeptide vascular endothelial growth factor (also known as vascular permeability factor) were measured and compared in eyes with and without proliferative diabetic retinopathy. Undiluted vitreous samples from 20 eyes were collected at the time of vitrectomy, and vascular endothelial growth factor levels were determined by using a time-resolved immunofluorometric assay. Vitreous vascular endothelial growth factor levels were significantly higher in eyes with proliferative diabetic retinopathy than in eyes without proliferative diabetic retinopathy (P = .006; Wilcoxon Rank Sum Test). The median vitreous concentration in the eyes with proliferative diabetic retinopathy was 29.1 pM and exceeded the known concentration required for the maximal proliferation of vascular endothelial cells in vitro. These data are consistent with vascular endothelial growth factor serving as a physiologically relevant angiogenic factor in proliferative diabetic retinopathy.

Keywords

Diabetic retinopathyVascular endothelial growth factorVitrectomyMedicineRetinopathyVascular endothelial growth factor AVascular permeabilityGrowth factorOphthalmologyEndocrinologyInternal medicineDiabetes mellitusVEGF receptorsVisual acuity

MeSH Terms

Diabetic RetinopathyEndothelial Growth FactorsFluoroimmunoassayHumansLymphokinesVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVitreous Body

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Publication Info

Year
1994
Type
article
Volume
118
Issue
4
Pages
445-450
Citations
1286
Access
Closed

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Cite This

A.P. Adamis, Joan W. Miller, Teresa Bernal et al. (1994). Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy. American Journal of Ophthalmology , 118 (4) , 445-450. https://doi.org/10.1016/s0002-9394(14)75794-0

Identifiers

DOI
10.1016/s0002-9394(14)75794-0
PMID
7943121

Data Quality

Data completeness: 81%