Irving L. Weissman

Stem cells, cancer, and cancer stem cells

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

Direct isolation of human central nervous system stem cells

Stem cells, which are clonogenic cells with self-renewal and multilineage differentiation properties, have the potential to replace or repair damaged tissue. We have directly is...

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

Neutrophils, the most common inflammatory leukocytes, have the most limited life span of all blood cells. After they undergo apoptosis, they are recognized and engulfed by macro...

Selectins: A family of adhesion receptors

Purification and Characterization of Mouse Hematopoietic Stem Cells

Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit e...

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

Stem cells are the natural units of embryonic generation, and also adult regeneration, of a variety of tissues. Recently, the list of tissues that use the model of differentiati...

Identification of a lineage of multipotent hematopoietic progenitors

ABSTRACT All multipotent hematopoietic progenitors in C57BL-Thy-1.1 bone marrow are divided among three subpopulations of Thy-1.1loSca-1+Lin−/loc-kit+cells:long-term reconstitut...

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation

Abstract A new transgenic mouse has been generated in which the proto-oncogene BCL-2 is ubiquitously overexpressed. H2K-BCL-2 transgenic mice overexpress BCL-2 in all cells of t...

Hematopoietic Stem Cells Need Two Signals to Prevent Apoptosis; Bcl-2 Can Provide One of These, Kitl/C-KIT Signaling the Other

Growth factors can cause cells to proliferate, differentiate, survive, or die. Distinguishing between these responses is difficult in multicellular, multiparameter systems. Yet ...

Stem Cells and Hematolymphoid Development

Abstract Hematopoietic stem cells (HSC) can be defined as clonogenic cells, each of which has the properties of both self-renewal and differentiation to all known blood cell typ...

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with eval...

Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application

▪ Abstract Stem cell biology is scientifically, clinically, and politically a current topic. The hematopoietic stem cell, the common ancestor of all types of blood cells, is one...

Index switching causes “spreading-of-signal” among multiplexed samples in Illumina HiSeq 4000 DNA sequencing

Abstract Illumina-based next generation sequencing (NGS) has accelerated biomedical discovery through its ability to generate thousands of gigabases of sequencing output per run...