Abstract
Interferon derived from human leukocytes, human fibroblasts, and mouse fibroblasts was found to inhibit the motility of cultured cells. It inhibits the tumor-induced motility of capillary endothelial cells as well as the spontaneous migration of other cell types. The ability of a given preparation of interferon to inhibit the motility of a given cell type is proportional to its antiviral activity in that particular cell type. Antiserum to human leukocyte interferon neutralizes both the motility-inhibitory activity and the antiviral activity of this preparation.
Keywords
MotilityInterferonCellAntiserumCell biologyCell typeBiologyInhibitory postsynaptic potentialChemistryImmunologyAntibodyBiochemistryEndocrinology
MeSH Terms
AnimalsAntineoplastic AgentsAntiviral AgentsCapillariesCattleCell MovementCellsCulturedEndotheliumFibroblastsHumansInterferonsLeukocytesMiceNeoplasms
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Publication Info
- Year
- 1980
- Type
- article
- Volume
- 208
- Issue
- 4443
- Pages
- 516-518
- Citations
- 325
- Access
- Closed
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Cite This
Danièle Brouty‐Boyé,
Bruce R. Zetter
(1980).
Inhibition of Cell Motility by Interferon.
Science
, 208
(4443)
, 516-518.
https://doi.org/10.1126/science.6154315
Identifiers
- DOI
- 10.1126/science.6154315
- PMID
- 6154315