Abstract
Antibiotic resistance represents an emerging global health threat. In this contribution we report all-atom molecular dynamics simulations of a bacterial protein in Acinetobacter baumanii. By using enhanced sampling we show the favorable internalization of the antibiotic via the CarO porin. This results correlates with the knockout or the mutation of the porin as a resistance mechanism.
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Florent Barbault,
Antonio Monari
(2025).
Internalization of Antibiotics by the Multi-Resistant Bacteria Acinetobacter baumannii through the CarO Outer Membrane Porin..
.
https://doi.org/10.26434/chemrxiv-2025-vgh6n
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- DOI
- 10.26434/chemrxiv-2025-vgh6n