InterPro in 2019: improving coverage, classification and access to protein sequence annotations

Abstract

The InterPro database (http://www.ebi.ac.uk/interpro/) classifies protein sequences into families and predicts the presence of functionally important domains and sites. Here, we report recent developments with InterPro (version 70.0) and its associated software, including an 18% growth in the size of the database in terms on new InterPro entries, updates to content, the inclusion of an additional entry type, refined modelling of discontinuous domains, and the development of a new programmatic interface and website. These developments extend and enrich the information provided by InterPro, and provide greater flexibility in terms of data access. We also show that InterPro's sequence coverage has kept pace with the growth of UniProtKB, and discuss how our evaluation of residue coverage may help guide future curation activities.

Keywords

MeSH Terms

Affiliated Institutions

• Institute of Structural and Molecular Biology GB
• European Bioinformatics Institute GB
• SIB Swiss Institute of Bioinformatics CH
• J. Craig Venter Institute US
• European Molecular Biology Laboratory DE
• University of Udine IT
• University of Manchester GB
• University of Delaware US
• Biobyte Solutions (Germany) DE
• University of Padua IT
• Medical Research Council GB
• University College London GB
• Georgetown University US
• Wellcome Trust GB
• MRC Laboratory of Molecular Biology GB
• University of Southern California US
• University of California, San Francisco US
• Fondazione Edmund Mach IT
• Georgetown University Medical Center US
• National Center for Biotechnology Information US

Related Publications