InterPro in 2022

Abstract

Abstract The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. Here, we report recent developments with InterPro (version 90.0) and its associated software, including updates to data content and to the website. These developments extend and enrich the information provided by InterPro, and provide a more user friendly access to the data. Additionally, we have worked on adding Pfam website features to the InterPro website, as the Pfam website will be retired in late 2022. We also show that InterPro's sequence coverage has kept pace with the growth of UniProtKB. Moreover, we report the development of a card game as a method of engaging the non-scientific community. Finally, we discuss the benefits and challenges brought by the use of artificial intelligence for protein structure prediction.

Keywords

Affiliated Institutions

• Institute of Structural and Molecular Biology GB
• University of Würzburg DE
• European Bioinformatics Institute GB
• SIB Swiss Institute of Bioinformatics CH
• European Molecular Biology Laboratory DE
• University of Cambridge GB
• Biobyte Solutions (Germany) DE
• University of Padua IT
• University of Delaware US
• Medical Research Council GB
• University College London GB
• Georgetown University US
• Yonsei University KR
• MRC Laboratory of Molecular Biology GB
• University of Southern California US
• Georgetown University Medical Center US
• Google (United States) US
• National Center for Biotechnology Information US
• National Institutes of Health US

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