Abstract
The success of clinical trials of sepsis therapies is predicated on the generation and interpretation of sound preclinical data. In this review, we have attempted to outline an evidence-based approach to the assessment of preclinical animal studies evaluating novel therapeutic interventions in sepsis.
Keywords
MedicineCritical appraisalClinical trialIntensive care medicineClinical study designSepsisData extractionMEDLINEAnimal modelAlternative medicineSurgeryPathologyInternal medicine
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Publication Info
- Year
- 1996
- Type
- review
- Volume
- 24
- Issue
- 12
- Pages
- 2059-2070
- Citations
- 133
- Access
- Closed
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Cite This
R. D. Piper,
Deborah J. Cook,
Roger C. Bone
et al.
(1996).
Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis.
Critical Care Medicine
, 24
(12)
, 2059-2070.
https://doi.org/10.1097/00003246-199612000-00021
Identifiers
- DOI
- 10.1097/00003246-199612000-00021