PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li; Clifford Yen; Danny Liaw; Katrina Podsypanina; Shikha Bose; Steven I. Wang; Janusz Puc; Christa Miliaresis; Linda Rodgers; W. Richard McCombie; Sandra H. Bigner; Beppino C. Giovanella; Michael Ittmann; Ben Tycko; Hanina Hibshoosh; Michael Wigler; Ramon Parsons

doi:10.1126/science.275.5308.1943

Abstract

Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN , that appears to be mutated at considerable frequency in human cancers. In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) of breast cancer cell lines and xenografts, and 17% (3/18) of primary glioblastomas. The predicted PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin, a protein that interacts with actin filaments at focal adhesions. These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions.

Keywords

PTENTensinCancer researchProtein tyrosine phosphataseBiologyTumor suppressor geneMetastasisProstate cancerPTPN11Gene productCancerGeneMutationCarcinogenesisKinaseSignal transductionPI3K/AKT/mTOR pathwayCell biologyGeneticsGene expression

MeSH Terms

Amino Acid SequenceBrain NeoplasmsBreast NeoplasmsChromosome MappingChromosomesHumanPair 10FemaleFrameshift MutationGenesTumor SuppressorGlioblastomaHumansMaleMicrofilament ProteinsMolecular Sequence DataMutationNeoplasm TransplantationNeoplasmsPTEN PhosphohydrolasePhosphoric Monoester HydrolasesPhosphotyrosineProstatic NeoplasmsProtein Tyrosine PhosphatasesProtein-Tyrosine KinasesSequence DeletionSequence HomologyAmino AcidTensinsTransplantationHeterologousTumor CellsCulturedTumor Suppressor Proteins

Affiliated Institutions

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Publication Info

Year: 1997
Type: article
Volume: 275
Issue: 5308
Pages: 1943-1947
Citations: 4788
Access: Closed

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APA Style

                            
                                
                                    Jing Li, 
                                
                                    Clifford Yen, 
                                
                                    Danny Liaw
                                
                                et al.
                            
                            (1997). 
                            <i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer. 
                            Science
                            , 275
                            (5308)
                            , 1943-1947.
                            https://doi.org/10.1126/science.275.5308.1943
                        

Identifiers

DOI: 10.1126/science.275.5308.1943
PMID: 9072974

Data Quality

Data completeness: 81%