Rameen Beroukhim

Absolute quantification of somatic DNA alterations in human cancer

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Integrated genomic characterization of endometrial carcinoma

The landscape of somatic copy-number alteration across human cancers

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to a...

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

High-throughput oncogene mutation profiling in human cancer

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

Abstract The classification of human tumors based on molecular criteria offers tremendous clinical potential; however, discerning critical and “druggable” effectors on a large s...

Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. Howe...

Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas

Abstract Purpose: A significant number of women with serous ovarian cancer are intrinsically refractory to platinum-based treatment. We analyzed somatic DNA copy number variatio...