Abstract
The integration and control of systemic immune responses depends on the regulated trafficking of lymphocytes. This lymphocyte “homing” process disperses the immunologic repertoire, directs lymphocyte subsets to the specialized microenvironments that control their differentiation and regulate their survival, and targets immune effector cells to sites of antigenic or microbial invasion. Recent advances reveal that the exquisite specificity of lymphocyte homing is determined by combinatorial “decision processes” involving multistep sequential engagement of adhesion and signaling receptors. These homing-related interactions are seamlessly integrated into the overall interaction of the lymphocyte with its environment and participate directly in the control of lymphocyte function, life-span, and population dynamics. In this article a review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulates the homeostasis of immunologic resources are proposed.
Keywords
Homing (biology)Lymphocyte homing receptorLymphocyteImmune systemBiologyEffectorImmunologyPopulationHomeostasisCell biologyCellCell adhesionGeneticsMedicineEcology
Affiliated Institutions
Related Publications
The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor.
The trafficking of lymphocytes from the blood and into lymphoid organs is controlled by tissue-selective lymphocyte interactions with specialized endothelial cells lining post c...
Innate Lymphoid Cells: 10 Years On
Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-residen...
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that m...
N<scp>aturally</scp>A<scp>rising</scp>CD4<sup>+</sup>R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>
▪ Abstract Naturally occurring CD4 + regulatory T cells, the majority of which express CD25, are engaged in dominant control of self-reactive T cells, contributing to the mainte...
Monoclonal antibodies to the integrin α−4 subunit inhibit the murine contact hypersensitivity response
Abstract Lymphocyte‐endothelial cell recognition is an active multistep process central to the pathophysiology of inflammation. In vitro models of lymphocyte adhesion predict th...
Publication Info
- Year
- 1996
- Type
- review
- Volume
- 272
- Issue
- 5258
- Pages
- 60-67
- Citations
- 2852
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
2852
OpenAlex
94
Influential
2266
CrossRef
Cite This
Eugene C. Butcher,
Louis J. Picker
(1996).
Lymphocyte Homing and Homeostasis.
Science
, 272
(5258)
, 60-67.
https://doi.org/10.1126/science.272.5258.60
Identifiers
- DOI
- 10.1126/science.272.5258.60
- PMID
- 8600538