Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

Roberto Cabeza; Marilyn Albert; Sylvie Belleville; Fergus I. M. Craik; Audrey Duarte; Cheryl L. Grady; Ulman Lindenberger; Lars Nyberg; Denise C. Park; Patricia A. Reuter‐Lorenz; Michael D. Rugg; Jason Steffener; M. Natasha Rajah

doi:10.1038/s41583-018-0068-2

Keywords

Cognitive declineCognitive agingCognitionCognitive reserveTerminologyPsychologyCognitive psychologyAgeingNeuroimagingDementiaNeuroscienceCognitive neuropsychologyCompensation (psychology)Cognitive neuroscienceNeuropsychologyMedicineCognitive impairmentDiseaseSocial psychology

Affiliated Institutions

Related Publications

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease

Nicolai Franzmeier , Emrah Düzel , Frank Jessen +53 more

Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may su...

2018 Brain 117 citations

Cognitive reserve☆

Yaakov Stern

The concept of reserve has been proposed to account for the disjunction between the degree of brain damage and its clinical outcome. This paper attempts to produce a coherent th...

2009 Neuropsychologia 2661 citations

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

Yaakov Stern , Eider M. Arenaza‐Urquijo , David Bartrés‐Faz +14 more

Abstract Several concepts, which in the aggregate get might be used to account for “resilience” against age‐ and disease‐related changes, have been the subject of much research....

2018 Alzheimer s & Dementia 1438 citations

Synergistic Effect of β-Amyloid and Neurodegeneration on Cognitive Decline in Clinically Normal Individuals

Elizabeth C. Mormino , Rebecca A. Betensky , Trey Hedden +5 more

The co-occurrence of Aβ and ND accelerates cognitive decline in CN individuals. Therefore, both factors are important to consider in upcoming secondary prevention trials targeti...

2014 JAMA Neurology 308 citations

Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline

Scott Ayton , Amir Fazlollahi , Pierrick Bourgeat +16 more

See Derry and Kent (doi:10.1093/awx167) for a scientific commentary on this article.The large variance in cognitive deterioration in subjects who test positive for amyloid-β by ...

2017 Brain 265 citations

Publication Info

Year: 2018
Type: review
Volume: 19
Issue: 11
Pages: 701-710
Citations: 1106
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1106

OpenAlex

Cite This

APA Style

                            
                                
                                    Roberto Cabeza, 
                                
                                    Marilyn Albert, 
                                
                                    Sylvie Belleville
                                
                                et al.
                            
                            (2018). 
                            Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing. 
                            Nature reviews. Neuroscience
                            , 19
                            (11)
                            , 701-710.
                            https://doi.org/10.1038/s41583-018-0068-2
                        

Identifiers

DOI: 10.1038/s41583-018-0068-2