Mapping of Functional Neural Pathways by Autoradiographic Survey of Local Metabolic Rate with [ <sup>14</sup> C]Deoxyglucose

Charles Kennedy; M. H. Des Rosiers; Jane Jehle; Martin Reivich; F. T. Sharpe; Louis Sokoloff

doi:10.1126/science.1114332

Abstract

If sufficient time has elapsed following an intravenous pulse of [ 14 C]deoxyglucose, the carbon-14 contents of the tissues of the central nervous system represent mainly the accumulated phosphorylated derivative of [ 14 C]deoxyglucose and reflect the rates of glucose consumption of the tissues. Altered functional activity alters metabolic activity and the uptake of [ 14 C]deoxyglucose in the tissues. By autoradiographic survey of sections of the central nervous system it is then possible to map all the regions with altered functional and metabolic activities in response to experimentally induced changes in functional state.

Keywords

TryptamineDeoxyglucoseIn vivoChemistryYield (engineering)Indole testIn vitroBiochemistryMetabolic pathwayHuman brainEnzymeBiologyStereochemistryNeurosciencePhysics

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Publication Info

Year: 1975
Type: article
Volume: 187
Issue: 4179
Pages: 850-853
Citations: 433
Access: Closed

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APA Style

                            
                                
                                    Charles Kennedy, 
                                
                                    M. H. Des Rosiers, 
                                
                                    Jane Jehle
                                
                                et al.
                            
                            (1975). 
                            Mapping of Functional Neural Pathways by Autoradiographic Survey of Local Metabolic Rate with [ <sup>14</sup> C]Deoxyglucose. 
                            Science
                            , 187
                            (4179)
                            , 850-853.
                            https://doi.org/10.1126/science.1114332
                        

Identifiers

DOI: 10.1126/science.1114332