Abstract
Critical Mediators Helper T cells are the immune system's ringmasters, having a multiplicity of functions that mediate the body's immune responses to infections. Depending on the type of infection, CD4 + helper T cells respond by secreting specific patterns of cytokines, which provide important cues to other subsets of immune cells. CD4 + T cells with distinct cytokine profiles have been viewed classically as separate lineages; however, there is mounting evidence that these cells may not be terminally differentiated but are in fact quite plastic. O'Shea and Paul (p. 1098 ) review the current understanding of CD4 + T cell subset differentiation and the underlying mechanisms that drive cell-lineage commitment.
Keywords
Immune systemBiologyLineage (genetic)ImmunologyT helper cellT cellCellular differentiationCell biologyCytokineGeneticsGene
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Publication Info
- Year
- 2010
- Type
- review
- Volume
- 327
- Issue
- 5969
- Pages
- 1098-1102
- Citations
- 1324
- Access
- Closed
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Cite This
John J. O’Shea,
William E. Paul
(2010).
Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 <sup>+</sup> T Cells.
Science
, 327
(5969)
, 1098-1102.
https://doi.org/10.1126/science.1178334
Identifiers
- DOI
- 10.1126/science.1178334