John J. O’Shea

Cytokine Signaling Modules in Inflammatory Responses

Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains

The structure of Janus kinases (JAKs) is unique among protein tyrosine kinases in having tandem, nonidentical kinase and pseudokinase domains. Despite its conservation in evolut...

Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice

Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in...

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 ⁺ T Cells

Critical Mediators Helper T cells are the immune system's ringmasters, having a multiplicity of functions that mediate the body's immune responses to infections. Depending on th...