Abstract

Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al. discuss how metabolism changes as cancer develops from a small, premalignant lesion to an aggressive primary tumor and then metastasizes. Metabolic vulnerabilities likely change with cancer progression, making the identification of general cancer-associated metabolic features difficult. The authors propose that a more targeted approach to tissues and vulnerabilities identified in patients may be more effective. Science , this issue p. eaaw5473

Keywords

CancerTumor progressionCancer cellBioinformaticsReprogrammingBiologyCancer researchMedicineInternal medicineGeneticsCell

MeSH Terms

AnimalsDisease ProgressionHumansMiceMolecular Targeted TherapyNeoplasm InvasivenessNeoplasm MetastasisNeoplasmsPrecancerous Conditions

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Publication Info

Year
2020
Type
review
Volume
368
Issue
6487
Citations
2307
Access
Closed

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2307
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33
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2008
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Cite This

Brandon Faubert, Ashley Solmonson, Ralph J. DeBerardinis (2020). Metabolic reprogramming and cancer progression. Science , 368 (6487) . https://doi.org/10.1126/science.aaw5473

Identifiers

DOI
10.1126/science.aaw5473
PMID
32273439
PMCID
PMC7227780

Data Quality

Data completeness: 90%