Abstract
We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies and low coverage. The signaling network controlling the yeast developmental transition to a filamentous form was clustered. Abstraction of a modular network-structure model identified module-organizer proteins and module-connector proteins. The functions of these proteins suggest that they are important for module function and intermodule communication.
Keywords
Modular designCluster analysisComputational biologyComputer scienceFunction (biology)AbstractionDistributed computingBiologyBiological systemCell biologyProgramming languageArtificial intelligence
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Publication Info
- Year
- 2003
- Type
- article
- Volume
- 100
- Issue
- 3
- Pages
- 1128-1133
- Citations
- 698
- Access
- Closed
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Cite This
Alexander Rives,
Timothy Galitski
(2003).
Modular organization of cellular networks.
Proceedings of the National Academy of Sciences
, 100
(3)
, 1128-1133.
https://doi.org/10.1073/pnas.0237338100
Identifiers
- DOI
- 10.1073/pnas.0237338100