mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

Keywords

Wnt signaling pathwayBiologyStem cellCell biologyPI3K/AKT/mTOR pathwayHair follicleSenescenceCell growthCancer researchSignal transductionGenetics

Affiliated Institutions

Related Publications

β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion

Alan Jian Zhu , Fiona M. Watt

ABSTRACT We found that cultured human keratinocytes with high proliferative potential, the putative epidermal stem cells, expressed a higher level of noncadherin-associated β- c...

1999 Development 240 citations

Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

Thomas Brabletz , Andreas Jung , Simone Reu +5 more

Invasion and dissemination of well-differentiated carcinomas are often associated with loss of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor c...

2001 Proceedings of the National Academy o... 1026 citations

Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo

Isaac Skromne , Claudio D. Stern

The posterior marginal zone (PMZ) of the chick embryo has Nieuwkoop centre-like properties: when transplanted to another part of the marginal zone, it induces a complete embryon...

2001 Development 157 citations

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Uri Gat , Ramanuj DasGupta , Linda Degenstein +1 more

1998 Cell 1084 citations

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Ravid Straussman , Teppei Morikawa , Kevin Shee +16 more

2012 Nature 1710 citations

Publication Info

Year: 2009
Type: article
Volume: 5
Issue: 3
Pages: 279-289
Citations: 369
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

369

OpenAlex

Cite This

APA Style

                            
                                
                                    Rogério M. Castilho, 
                                
                                    Cristiane H. Squarize, 
                                
                                    Lewis A. Chodosh
                                
                                et al.
                            
                            (2009). 
                            mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging. 
                            Cell stem cell
                            , 5
                            (3)
                            , 279-289.
                            https://doi.org/10.1016/j.stem.2009.06.017
                        

Identifiers

DOI: 10.1016/j.stem.2009.06.017