Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

George A. Carlson; Thekla S. Diehl; Georges Lévesque; Kelly Johnson‐Wood; Michael Lee; Peter Seubert; Angela Davis; Dora Kholodenko; Ruth Motter; Robin Sherrington; Billie J. Perry; Hong Yao; Robert Strome; Ivan Lieberburg; Johanna M. Rommens; Soyeon Kim; Dale Schenk; Paul Fraser; Peter St George‐Hyslop; Dennis J. Selkoe; Martin Citron; David Westaway; Weiming Xia

doi:10.1038/nm0197-67

Keywords

PresenilinAmyloid precursor proteinMutantGenetically modified mouseTransfectionTransgeneBACE1-ASMolecular biologyBiologySecretionWild typeMutationAmyloid betaAlzheimer's diseaseChemistryGeneEndocrinologyBiochemistryInternal medicinePeptideMedicineDisease

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Publication Info

Year: 1997
Type: article
Volume: 3
Issue: 1
Pages: 67-72
Citations: 1260
Access: Closed

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APA Style

                            
                                
                                    George A. Carlson, 
                                
                                    Thekla S. Diehl, 
                                
                                    Georges Lévesque
                                
                                et al.
                            
                            (1997). 
                            Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. 
                            Nature Medicine
                            , 3
                            (1)
                            , 67-72.
                            https://doi.org/10.1038/nm0197-67
                        

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DOI: 10.1038/nm0197-67