Neurotoxic reactive astrocytes are induced by activated microglia

Keywords

MicrogliaNeuroscienceAxotomyAmyotrophic lateral sclerosisNeuroinflammationCentral nervous systemNeurogliaBiologyNeurodegenerationSynaptogenesisAstrocyteMultiple sclerosisPhagocytosisMedicineDiseaseInflammationCell biologyImmunologyPathology

Affiliated Institutions

Related Publications

Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration

Jeffrey M. Craft , D. Martin Watterson , Linda J. Van Eldik

Abstract Using a human amyloid β (Aβ) intracerebroventricular infusion mouse model of Alzheimer's disease‐related injury, we previously demonstrated that systemic administration...

2005 Glia 109 citations

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

Daniel C. Lee , Justin Rizer , Maj-Linda B. Selenica +7 more

2010 Journal of Neuroinflammation 282 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

D. Cory Adamson , Brigitte Wildemann , Masayuki Sasaki +5 more

Indirect mechanisms are implicated in the pathogenesis of the dementia associated with human immunodeficiency virus-type 1 (HIV-1) infection. Proinflammatory molecules such as t...

1996 Science 419 citations

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)

Martin Ramsden , Linda Kotilinek , Colleen L. Forster +9 more

Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tau P301L )4510 mouse expresses the P301L mutation in tau (4R0N) associated with f...

2005 Journal of Neuroscience 705 citations

Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse

Marcia N. Gordon , Leigh A. Holcomb , Paul Jantzen +7 more

2002 Experimental Neurology 246 citations

Publication Info

Year: 2017
Type: article
Volume: 541
Issue: 7638
Pages: 481-487
Citations: 7396
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Neurotoxic reactive astrocytes are induced by activated microglia

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

7396

OpenAlex

Cite This

APA Style

                            
                                
                                    Shane A. Liddelow, 
                                
                                    Kevin A. Guttenplan, 
                                
                                    Laura Clarke
                                
                                et al.
                            
                            (2017). 
                            Neurotoxic reactive astrocytes are induced by activated microglia. 
                            Nature
                            , 541
                            (7638)
                            , 481-487.
                            https://doi.org/10.1038/nature21029
                        

Identifiers

DOI: 10.1038/nature21029